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KMID : 0881720180330050383
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Journal of Food Hygiene and Safety
2018 Volume.33 No. 5 p.383 ~ p.389
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Immunomodulation by Bioprocessed Polysaccharides from Lentinus edodes Mycelia Cultures with Rice Bran in the Salmonella Gallinarum-infected Chicken Macrophages
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Lee Hyung-Tae
Lee Sang-Jong
Yoon Jang-Won
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Abstract
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In this study, we investigated the effect of bioprocessed polysaccharides (BPPs) from the liquid culture of Lentinus edodes fungal mycelia containing rice bran (BPP-RB) on a chicken-derived macrophage cell line, HD-11, when infected with Salmonella Gallinarum, an etiological agent of fowl typhoid. Experimental results demonstrated water extract of BPP-RB did not show growth inhibitory effects on S. Gallinarum 277. Protein expression profiles were also not altered by its treatment. Nonetheless, it could (i) enhance phagocytic activity of HD-11 cells, (ii) activate the transcriptional expression of Th1-type cytokines such as tumor necrosis factor-α and interleukin (IL)-1β, iNOS, as well as an immunosuppressive cytokine IL-10, and (iii) negatively regulate Th2-type cytokines such as IL-4 and IL-6. Together results suggest that BPP-RB may be applicable for preventing fowl typhoid or other Salmonella infections in poultry farms as a potential feed additive.
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KEYWORD
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Rice bran, Salmonella Gallinarum, Chicken macrophage, Immunomodulation
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